Health and Medicine
Synthesis and ProcessingNanodiscs activated by an external magnetic field could provide a research tool for studying neural responses
Device FabricationA diagnostic device based on nuclear magnetic resonance that could be used to detect fatty liver disease
Soft MatterContracting fibers could be used as artificial muscles for prosthetic limbs or valves in medical devices
Nanodiscs activated by an external magnetic field could provide a research tool for studying neural responses
A diagnostic device based on nuclear magnetic resonance that could be used to detect fatty liver disease
Contracting fibers could be used as artificial muscles for prosthetic limbs or valves in medical devices
Pioneering Improvements in Health Outcomes
DMSE researchers are leading the field in applying materials science and engineering to the human body. They have built a diagnostic device that uses nuclear magnetic resonance to detect fatty liver disease. The tool helps doctors find the disease before it progresses to liver failure. Researchers have also developed artificial muscles that can stretch more than 1,000 percent of their size and could be used in lighter-weight prosthetic limbs. And they can induce mechanical stimulation of the body’s neural cells using an injection of tiny particles. That brings science a step closer to bioelectronic medicine, which can stimulate individual organs or parts of the body without drugs or electrodes.
A sensor developed in DMSE could help doctors detect liver damage before it progresses.
Materials and Methods for Medical Advancement
The inventiveness of DMSE researchers in health and science is limitless. One important class of materials they use is soft matter—polymers for fibers that deliver drugs to the brain, for example, or get molded into valves for medical devices. DMSE researchers use synthesis and processing techniques to create materials that can mimic the response of human tissue, diagnose disease, or help heal and repair an organ. And they build devices—sensors that can measure oxygen levels in diseased tissue or silicone tubes that can be implanted in the bladder and slowly release drugs to treat bladder disease.
In vivo photopharmacology enabled by multifunctional fibers
Developed an approach to deliver light and drugs on demand through a fiber and applied it to control behavior in mice. The experiment paves the way for future clinical applications of photopharmacology, which involves photosensitive molecules that upon illumination bind to receptors to enhance or suppress the activity of certain cells.
Excited state non-adiabatic dynamics of large photoswitchable molecules using a chemically transferable machine learning potential
We developed a machine learning approach that accelerates the process of identifying photoswitches, molecules that activate, or “turn on,” when exposed to light.