Krystyn J. Van Vliet

  • Michael (1949) and Sonja Koerner Professor of Materials Science and Engineering
  • Associate Provost
  • ScB, Materials Engineering, Brown University, 1998
  • PhD, Materials Engineering, MIT, 2002

Biophysics; Biotechnology; Computational Materials Science; Mechanical Behavior of Materials; Metallurgy; Nanotechnology; Polymers; Structural Materials; Composites; Surfaces, Interfaces, and Thin Films

Krystyn J. Van Vliet

Research

Professor Van Vliet's group studies material chemomechanics: material behavior at the interface of mechanics, chemistry, physics, and biology. She focuses on thermodynamically metastable surfaces and interfaces, in which stress-assisted chemical reaction kinetics are notoriously difficult to analyze via either experiment or simulation. The mechanisms of this coupling in cell-material interactions are incompletely understood, due to both biological complexity and lack of appropriate experimental and computational tools, but are key to design of materials that modulate cell adhesion for drug uptake and differentiation. Her long-term goal is to predict and modulate key functions of biological cells by drawing analogies to the coupled chemical/mechanical behavior of structurally simpler, nonbiological material interfaces and nanocomposites. These integrated experimental and computational efforts include three main thrusts: (1) chemomechanical mapping of nanocomposite surfaces including living cells; (2) mechanics of amorphous and viscoelastic surfaces and nanostructures; and (3) chemical kinetics in mechanically strained, nanoscale material interfaces. Her group has used this interdisciplinary application of mechanical and chemical forces to rapidly map environment-structure-property relations in engineered materials, and to predict the binding kinetics of individual molecules on living cells. These studies have shown that the stiffness of materials to which molecular ligands are tethered can directly affect kinetics of ligand-receptor interactions at cell surfaces.

Professor Van Vliet serves as the faculty supervisor of the DMSE Nanomechanical Technology Laboratory, has co-developed new undergraduate core classes, and has implemented new programs to retain underrepresented minority students.

Recent News

Helping blood cells regenerate after radiation therapy

Patients with blood cancers such as leukemia and lymphoma are often treated by irradiating their bone marrow to destroy the diseased cells. After the treatment, patients are vulnerable to infection and fatigue until new blood cells grow back. MIT researchers have now devised a way to…   more

New analysis explains role of defects in metal oxides

Sometimes things that are technically defects, such as imperfections in a material’s crystal lattice, can actually produce changes in properties that open up new kinds of useful applications. New research from a team at MIT shows that such imperfections in a family of materials known as…   more

Krystyn Van Vliet named associate provost

Krystyn Van Vliet, an MIT professor in the departments of Materials Science and Engineering and Biological Engineering, with wide-ranging interests in research and innovation, has been named as the Institute’s new associate provost. She will assume this role on Sept. 1. Van Vliet succeeds…   more

High-temperature devices made from films that bend as they “breathe”

Carrying out maintenance tasks inside a nuclear plant puts severe strains on equipment, due to extreme temperatures that are hard for components to endure without degrading. Now, researchers at MIT and elsewhere have come up with a radically new way to make actuators that could be used in such…   more

MIT.nano has its first public showing

The brand new, state-of-the-art MIT.nano building had its first public showing recently. The new building promises to be an enormously influential toolbox for many MIT departments, especially DMSE. Faculty and other researchers are excited for its completion slated for 2018. Krystyn Van…   more

Toward all-solid lithium batteries

"Most batteries are composed of two solid, electrochemically active layers called electrodes, separated by a polymer membrane infused with a liquid or gel electrolyte. But recent research has explored the possibility of all-solid-state batteries, in which the liquid (and potentially flammable)…   more

Publications

2019

Q. Zhu, Van Vliet, K. J., Holten-Andersen, N., and Miserez, A., “A Double‐Layer Mechanochromic Hydrogel with Multidirectional Force Sensing and Encryption Capability”, Advanced Functional Materials, vol. 29, no. 14. Wiley, p. 1808191, 2019.

2018

D. Veysset et al., “High-velocity micro-particle impact on gelatin and synthetic hydrogel”, Journal of the Mechanical Behavior of Biomedical Materials, vol. 86. pp. 71-76, 2018.
Y. -T. Chi, Youssef, M., Sun, L., Van Vliet, K. J., and Yildiz, B., “Accessible switching of electronic defect type in SrTi O 3 via biaxial strain”, Physical Review Materials, vol. 2. 2018.
E. Makhija et al., “Mechanical Strain Alters Cellular and Nuclear Dynamics at Early Stages of Oligodendrocyte Differentiation”, Frontiers in Cellular Neuroscience, vol. 12. 2018.
A. W. Holle et al., “Cell–Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research”, Nano Letters, vol. 18. pp. 1-8, 2018.
J. G. Swallow et al., “Atomic Resolution Imaging of Nanoscale Chemical Expansion in PrtxCe1–xO2−δ during In Situ Heating”, ACS Nano, vol. 12. pp. 1359-1372, 2018.
D. Espinosa-Hoyos et al., “Engineered 3D-printed artificial axons”, Scientific Reports, vol. 8. 2018.
F. D. Liu, Tam, K., Pishesha, N., Poon, Z., and Van Vliet, K. J., “Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome”, Stem Cell Research & Therapy, vol. 9. 2018.
A. S. Mijailovic, Qing, B., Fortunato, D., and Van Vliet, K. J., “Characterizing viscoelastic mechanical properties of highly compliant polymers and biological tissues using impact indentation”, Acta Biomaterialia, vol. 71. pp. 388-397, 2018.
J. G. Swallow, Youssef, M., and Van Vliet, K. J., “Defect-Mediated Mechanics in Non-Stoichiometric Oxide Films”, MRS Advances, vol. 3. pp. 537-545, 2018.
F. P. McGrogan, Raja, S. N., Chiang, Y. -M., and Van Vliet, K. J., “Electrochemomechanical Fatigue: Decoupling Mechanisms of Fracture-Induced Performance Degradation in LiX Mn2 O4”, Journal of The Electrochemical Society, vol. 165. p. A2458—A2466, 2018.

2017

M. Youssef, Van Vliet, K. J., and Yildiz, B., “Polarizing Oxygen Vacancies in Insulating Metal Oxides under a High Electric Field”, Physical Review Letters, vol. 119. 2017.
J. G. Swallow et al., “Dynamic chemical expansion of thin-film non-stoichiometric oxides at extreme temperatures”, Nature Materials. 2017.
F. D. Liu, Pishesha, N., Poon, Z., Kaushik, T., and Van Vliet, K. J., “Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery”, ACS Biomaterials Science \& Engineering, vol. 3. pp. 3292-3306, 2017.
P. G. Cai et al., “Temporal Variation in Single-Cell Power-Law Rheology Spans the Ensemble Variation of Cell Population”, Biophysical Journal, vol. 113. pp. 671-678, 2017.
A. Jagielska et al., “Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression”, Frontiers in Cellular Neuroscience, vol. 11. 2017.
M. Youssef, Yildiz, B., and Van Vliet, K. J., “Thermomechanical stabilization of electron small polarons in SrTi O 3 assessed by the quasiharmonic approximation”, Physical Review B, vol. 95. 2017.
F. P. McGrogan et al., “Compliant Yet Brittle Mechanical Behavior of Li2S-P2S5 Lithium-Ion-Conducting Solid Electrolyte”, Advanced Energy Materials, vol. 7. p. 1602011, 2017.
D. Espinosa-Hoyos, Du, H., Fang, N. X., and Van Vliet, K. J., “Poly(HDDA)-Based Polymers for Microfabrication and Mechanobiology”, MRS Advances, vol. 2. pp. 1315-1321, 2017.
F. P. McGrogan, Bishop, S. R., Chiang, Y. -M., and Van Vliet, K. J., “Connecting Particle Fracture with Electrochemical Impedance in Li $_\textrmX$ Mn $_\textrm2$ O $_\textrm4$”, Journal of The Electrochemical Society, vol. 164. p. A3709—A3717, 2017.

2016

M. Kabir and Van Vliet, K. J., “Kinetics of Topological Stone-Wales Defect Formation in Single Walled Carbon Nanotubes”, Journal of Physical Chemistry C, vol. 120. pp. 1989-1993, 2016.

2015

N. Ferralis, Jagannathan, D., Grossman, J. C., and Van Vliet, K. J., “Unintended consequences: Why carbonation can dominate in microscale hydration of calcium silicates”, Journal of Materials Research, vol. 30. pp. 2425-2433, 2015.
M. B. Pinson et al., “Hysteresis from Multiscale Porosity: Modeling Water Sorption and Shrinkage in Cement Paste”, Physical Review Applied, vol. 3. p. 064009, 2015.
W. Herbert, Krishnamoorthy, A., Rands, L., Van Vliet, K. J., and Yildiz, B., “Magnetic diffusion anomaly at the Neel temperature of pyrrhotite, Fe(1-x)S.”, Physical chemistry chemical physics : PCCP, vol. 17. pp. 11036-41, 2015.
W. Herbert, Krishnamoorthy, A., Yildiz, B., and Van Vliet, K. J., “Diffusion-limited kinetics of the antiferromagnetic to ferrimagnetic lambda-transition in Fe1-xS”, Applied Physics Letters, vol. 106. p. 092402, 2015.
Z. Poon et al., “Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors From Mesenchymal Stromal Cells”, Stem Cells Translational Medicine, vol. 4. pp. 56-65, 2015.

2014

M. J. Whitfield, Bono, D. C., Wei, L., and Van Vliet, K. J., “High-throughput corrosion quantification in varied microenvironments”, Corrosion Science, vol. 88. pp. 481-486, 2014.
W. C. Lee et al., “Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency”, Proceedings of the National Academy of Sciences of the United States of America, vol. 111. pp. E4409 - E4418, 2014.
F. W. Herbert, Krishnamoorthy, A., Van Vliet, K. J., and Yildiz, B., “Quantification of Electronic Band Gap and Surface States on FeS2(100) (vol 618, pg 53, 2013)”, Surface Science, vol. 628. pp. 159-159, 2014.
M. J. A. Qomi et al., “Combinatorial molecular optimization of cement hydrates.”, Nature communications, vol. 5. pp. 4960-4960, 2014.
R. Martinelli et al., “Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance”, Journal of Cell Science, vol. 127. pp. 3720-3734, 2014.
F. W. Herbert, Krishnamoorthy, A., Ma, W., Van Vliet, K. J., and Yildiz, B., “Dynamics of point defect formation, clustering and pit initiation on the pyrite surface”, Electrochimica Acta, vol. 127. pp. 416-426, 2014.
J. G. Swallow et al., “Chemomechanics of ionically conductive ceramics for electrical energy conversion and storage”, Journal of Electroceramics, vol. 32. pp. 3-27, 2014.
S. C. B. Herath et al., “Quantification of Magnetically Induced Changes in ECM Local Apparent Stiffness”, Biophysical Journal, vol. 106. pp. 332-341, 2014.
R. Martinelli, Zeiger, A. S., Withfield, M., Van Vliet, K. J., Greenwood, J., and Carman, C., “Cellular and biomechanical determinants of leukocyte diapedesis migration route”, Angiogenesis, vol. 17. pp. 299-299, 2014.
J. M. Maloney and Van Vliet, K. J., “Chemoenvironmental modulators of fluidity in the suspended biological cell”, Soft Matter, vol. 10. pp. 8031-8042, 2014.
J. G. Swallow, Woodford, W. H., McGrogan, F. P., Ferralis, N., Chiang, Y. M., and Van Vliet, K. J., “Effect of Electrochemical Charging on Elastoplastic Properties and Fracture Toughness of LixCoO2”, Journal of the Electrochemical Society, vol. 161. pp. F3084 - F3090, 2014.

2013

K. Li, Whitfield, M., and Van Vliet, K. J., “Beating the bugs: roles of microbial biofilms in corrosion”, Corrosion Reviews, vol. 31. pp. 73-84, 2013.
F. W. Herbert, Krishnamoorthy, A., Van Vliet, K. J., and Yildiz, B., “Quantification of electronic band gap and surface states on FeS2(100)”, Surface Science, vol. 618. pp. 53-61, 2013.
M. J. Whitfield, Lee, W. C. J., and Van Vliet, K. J., “Onset of heterogeneity in culture-expanded bone marrow stromal cells”, Stem Cell Research, vol. 11. pp. 1365-1377, 2013.
J. M. Maloney, Lehnhardt, E., Long, A. F., and Van Vliet, K. J., “Mechanical Fluidity of Fully Suspended Biological Cells”, Biophysical Journal, vol. 105. pp. 1767-1777, 2013.
A. Jagielska, Wilhite, K. D., and Van Vliet, K. J., “Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation”, Plos One, vol. 8. 2013.
P. G. Cai et al., “Quantifying Cell-to-Cell Variation in Power-Law Rheology”, Biophysical Journal, vol. 105. pp. 1093-1102, 2013.
N. F. Reuel et al., “Emergent Properties of Nanosensor Arrays: Applications for Monitoring IgG Affinity Distributions, Weakly Affined Hypermannosylation, and Colony Selection for Biomanufacturing”, Acs Nano, vol. 7. pp. 7472-7482, 2013.
A. S. Zeiger, Hinton, B., and Van Vliet, K. J., “Why the dish makes a difference: Quantitative comparison of polystyrene culture surfaces”, Acta Biomaterialia, vol. 9. pp. 7354-7361, 2013.
I. Kalcioglu, Mrozek, R. A., Mahmoodian, R., VanLandingham, M. R., Lenhart, J. L., and Van Vliet, K. J., “Tunable mechanical behavior of synthetic organogels as biofidelic tissue simulants”, Journal of Biomechanics, vol. 46. pp. 1583-1591, 2013.
R. K. Paradise, Whitfield, M. J., Lauffenburger, D. A., and Van Vliet, K. J., “Directional cell migration in an extracellular pH gradient: A model study with an engineered cell line and primary microvascular endothelial cells”, Experimental Cell Research, vol. 319. pp. 487-497, 2013.
A. Krishnamoorthy, Herbert, W., Yip, S., Van Vliet, K. J., and Yildiz, B., “Electronic states of intrinsic surface and bulk vacancies in FeS2”, Journal of Physics-Condensed Matter, vol. 25. 2013.
K. E. Strawhecker, Hsieh, A. J., Chantawansri, T. L., Kalcioglu, I., and Van Vliet, K. J., “Influence of microstructure on micro-/nano-mechanical measurements of select model transparent poly(urethane urea) elastomers”, Polymer, vol. 54. pp. 901-908, 2013.
O. Kuksenok et al., “Chemo-responsive, self-oscillating gels that undergo biomimetic communication”, Chemical Society Reviews, vol. 42. pp. 7257-7277, 2013.
P. A. Bonnaud, Ji, Q., and Van Vliet, K. J., “Effects of elevated temperature on the structure and properties of calcium-silicate-hydrate gels: the role of confined water”, Soft Matter, vol. 9. pp. 6418-6429, 2013.

2012

A. Jagielska, Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., and Franklin, R. J. M., “Mechanical Environment Modulates Biological Properties of Oligodendrocyte Progenitor Cells”, Stem Cells and Development, vol. 21. pp. 2905-2914, 2012.
P. A. Bonnaud, Ji, Q., Coasne, B., Pellenq, R. J. -M., and Van Vliet, K. J., “Thermodynamics of Water Confined in Porous Calcium-Silicate-Hydrates”, Langmuir, vol. 28. pp. 11422-11432, 2012.
M. Qu, Woodford, W. H., Maloney, J. M., Carter, C., Chiang, Y. M., and Van Vliet, K. J., “Nanomechanical Quantification of Elastic, Plastic, and Fracture Properties of LiCoO2”, Advanced Energy Materials, vol. 2. pp. 940-944, 2012.
I. C. Chen, Kuksenok, O., Yashin, V. V., Balazs, A. C., and Van Vliet, K. J., “Mechanical Resuscitation of Chemical Oscillations in Belousov-Zhabotinsky Gels”, Advanced Functional Materials, vol. 22. pp. 2535-2541, 2012.
A. S. Zeiger, Loe, F. C., Li, R., Raghunath, M., and Van Vliet, K. J., “Macromolecular Crowding Directs Extracellular Matrix Organization and Mesenchymal Stem Cell Behavior”, Plos One, vol. 7. 2012.
K. J. Van Vliet et al., “Set in stone? A perspective on the concrete sustainability challenge”, Mrs Bulletin, vol. 37. pp. 395-402, 2012.
F. W. Herbert, Van Vliet, K. J., and Yildiz, B., “Plasticity-induced oxidation reactivity on Ni(100) studied by scanning tunneling spectroscopy”, Mrs Communications, vol. 2. pp. 23-27, 2012.
M. Kabir and Van Vliet, K. J., “Reversible mechanism for spin crossover in transition-metal cyanides”, Physical Review B, vol. 85. 2012.
Q. Ji, Pellenq, R. J. -M., and Van Vliet, K. J., “Comparison of computational water models for simulation of calcium-silicate-hydrate”, Computational Materials Science, vol. 53. pp. 234-240, 2012.
A. Jagielska, Norman, A., Whyte, G., Franklin, R. J. M., Guck, J., and Van Vliet, K. J., “Differentiation, Migration, Proliferation, and Survival of Oligodendrocyte Precursor Cells is Modulated by Mechanical Properties of their Environment”, Biophysical Journal, vol. 102. p. 704A - 704A, 2012.
M. Vandamme, Tweedie, C. A., Constantinides, G., Ulm, F. -J., and Van Vliet, K. J., “Quantifying plasticity-independent creep compliance and relaxation of viscoelastoplastic materials under contact loading”, Journal of Materials Research, vol. 27. pp. 302-312, 2012.
I. Kalcioglu, Mahmoodian, R., Hu, Y., Suo, Z., and Van Vliet, K. J., “From macro- to microscale poroelastic characterization of polymeric hydrogels via indentation”, Soft Matter, vol. 8. pp. 3393-3398, 2012.
E. A. Maresov, Kolmakov, G. V., Yashin, V. V., Van Vliet, K. J., and Balazs, A. C., “Modeling the making and breaking of bonds as an elastic microcapsule moves over a compliant substrate”, Soft Matter, vol. 8. pp. 77-85, 2012.

2011

S. R. Peyton et al., “Use of Three-Dimensional Spheroids of Hepatocyte-Derived Reporter Cells to Study the Effects of Intracellular Fat Accumulation and Subsequent Cytokine Exposure”, Biotechnology and Bioengineering, vol. 108. pp. 1181-1193, 2011.
F. Deng and Van Vliet, K. J., “Prediction of elastic properties for polymer-particle nanocomposites exhibiting an interphase”, Nanotechnology, vol. 22. 2011.
C. M. Williams, Mehta, G., Peyton, S. R., Zeiger, A. S., Van Vliet, K. J., and Griffith, L. G., “Autocrine-Controlled Formation and Function of Tissue-Like Aggregates by Primary Hepatocytes in Micropatterned Hydrogel Arrays”, Tissue Engineering Part A, vol. 17. pp. 1055-1068, 2011.
C. -H. Lee, Bose, S., Van Vliet, K. J., Karp, J. M., and Karnik, R., “Studying cell rolling trajectories on asymmetric receptor patterns.”, Journal of visualized experiments : JoVE. 2011.
A. Jagielska, Norman, A., Whyte, G., Franklin, R. J. M., Guck, J., and Van Vliet, K. J., “Changes in Mechanical Properties Occur During Differentiation Within the Oligodendrocyte Lineage”, Biophysical Journal, vol. 100. pp. 483-483, 2011.
A. S. Zeiger, Loe, F. C., Raghunath, M., and Van Vliet, K. J., “Influence of Altered Local Effective Concentration on Cytoskeletal and Ecm Structure in Human Mesenchymal Stem Cells”, Biophysical Journal, vol. 100. pp. 599-599, 2011.
F. C. Loe, Van Vliet, K. J., and Raghunath, M., “Macromolecular Crowding Facilitates Adipogenic Microenvironments for Human Mesenchymal Stem Cells”, Biophysical Journal, vol. 100. pp. 622-622, 2011.
J. M. Maloney and Van Vliet, K. J., “The Origin and Limits of Natural Variation in Cell Mechanical Behavior”, Biophysical Journal, vol. 100. pp. 442-442, 2011.
R. K. Paradise, Lauffenburger, D. A., and Van Vliet, K. J., “Regulation of Integrin Activation in Acidic Extracellular Microenvironments”, Biophysical Journal, vol. 100. pp. 551-551, 2011.
R. K. Paradise, Lauffenburger, D. A., and Van Vliet, K. J., “Acidic Extracellular pH Promotes Activation of Integrin alpha(v)beta(3)”, Plos One, vol. 6. 2011.
C. -H. Lee, Bose, S., Van Vliet, K. J., Karp, J. M., and Karnik, R., “Examining the Lateral Displacement of HL60 Cells Rolling on Asymmetric P-Selectin Patterns”, Langmuir, vol. 27. pp. 240-249, 2011.
N. Artzi, Zeiger, A. S., Boehning, F., Ramos, A. bon, Van Vliet, K. J., and Edelman, E. R., “Tuning adhesion failure strength for tissue-specific applications”, Acta Biomaterialia, vol. 7. pp. 67-74, 2011.
Q. Guo, Zhang, L., Zeiger, A. S., Li, Y., Van Vliet, K. J., and Thompson, C. V., “Compositional dependence of Young's moduli for amorphous Cu-Zr films measured using combinatorial deposition on microscale cantilever arrays”, Scripta Materialia, vol. 64. pp. 41-44, 2011.
I. Kalcioglu et al., “Dynamic impact indentation of hydrated biological tissues and tissue surrogate gels”, Philosophical Magazine, vol. 91. pp. 1339-1355, 2011.
W. C. Lee, Bhagat, A. A. S., Huang, S., Van Vliet, K. J., Han, J., and Lim, C. T., “High-throughput cell cycle synchronization using inertial forces in spiral microchannels”, Lab on a Chip, vol. 11. pp. 1359-1367, 2011.
M. Qu, Deng, F., Kalkhoran, S. M., Gouldstone, A., Robisson, A., and Van Vliet, K. J., “Nanoscale visualization and multiscale mechanical implications of bound rubber interphases in rubber-carbon black nanocomposites”, Soft Matter, vol. 7. pp. 1066-1077, 2011.
I. C. Chen, Kuksenok, O., Yashin, V. V., Moslin, R. M., Balazs, A. C., and Van Vliet, K. J., “Shape- and size-dependent patterns in self-oscillating polymer gels”, Soft Matter, vol. 7. pp. 3141-3146, 2011.
M. Qu, Meth, J. S., Blackman, G. S., Cohen, G. M., Sharp, K. G., and Van Vliet, K. J., “Tailoring and probing particle-polymer interactions in PMMA/silica nanocomposites”, Soft Matter, vol. 7. pp. 8401-8408, 2011.

2010

C. A. Fernandez et al., “The Anti-angiogenic Peptide, Loop 6, Binds Insulin-like Growth Factor-1 Receptor”, Journal of Biological Chemistry, vol. 285. pp. 41886-41895, 2010.
T. M. Shazly, Baker, A. B., Naber, J. R., Bon, A., Van Vliet, K. J., and Edelman, E. R., “Augmentation of postswelling surgical sealant potential of adhesive hydrogels”, Journal of Biomedical Materials Research Part A, vol. 95A. pp. 1159-1169, 2010.
M. Kotecki, Zeiger, A. S., Van Vliet, K. J., and Herman, I. M., “Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness”, Microvascular Research, vol. 80. pp. 339-348, 2010.
M. -H. Ham et al., “Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate”, Nature Chemistry, vol. 2. pp. 929-936, 2010.
J. M. Maloney et al., “Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State”, Biophysical Journal, vol. 99. pp. 2479-2487, 2010.
M. Kabir, Lau, T. T., Lin, X., Yip, S., and Van Vliet, K. J., “Effects of vacancy-solute clusters on diffusivity in metastable Fe-C alloys”, Physical Review B, vol. 82. 2010.
Y. Mei et al., “Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells”, Nature Materials, vol. 9. pp. 768-778, 2010.
M. Kabir, Lau, T. T., Rodney, D., Yip, S., and Van Vliet, K. J., “Predicting Dislocation Climb and Creep from Explicit Atomistic Details”, Physical Review Letters, vol. 105. 2010.
S. Lee, Zeiger, A. S., Maloney, J. M., Kotecki, M., Van Vliet, K. J., and Herman, I. M., “Pericyte actomyosin-mediated contraction at the cell-material interface can modulate the microvascular niche”, Journal of Physics-Condensed Matter, vol. 22. 2010.
S. Buell, Rutledge, G. C., and Van Vliet, K. J., “Predicting Polymer Nanofiber Interactions via Molecular Simulations”, Acs Applied Materials & Interfaces, vol. 2. pp. 1164-1172, 2010.
J. Y. Mao, Belcher, A. M., and Van Vliet, K. J., “Genetically Engineered Phage Fibers and Coatings for Antibacterial Applications”, Advanced Functional Materials, vol. 20. pp. 209-214, 2010.
F. -J. Ulm et al., “Does microstructure matter for statistical nanoindentation techniques?”, Cement & Concrete Composites, vol. 32. pp. 92-99, 2010.
R. Krishnan, Lauffenburger, D. A., and Van Vliet, K. J., “Extracellular pH and Regulation of Integrin-Ligand Interactions”, Biophysical Journal, vol. 98. p. 40A - 40A, 2010.
K. J. Van Vliet, INSTRUMENTATION AND EXPERIMENTATION. 2010.

2009

J. A. Lichter, Van Vliet, K. J., and Rubner, M. F., “Design of Antibacterial Surfaces and Interfaces: Polyelectrolyte Multilayers as a Multifunctional Platform”, Macromolecules, vol. 42. pp. 8573-8586, 2009.
R. Krishnan, Walton, E. B., and Van Vliet, K. J., “Characterizing rare-event property distributions via replicate molecular dynamics simulations of proteins”, Journal of Molecular Modeling, vol. 15. pp. 1383-1389, 2009.
R. J. -M. Pellenq et al., “A realistic molecular model of cement hydrates”, Proceedings of the National Academy of Sciences of the United States of America, vol. 106. pp. 16102-16107, 2009.
J. M. Kranenburg, Tweedie, C. A., Van Vliet, K. J., and Schubert, U. S., “Challenges and Progress in High-Throughput Screening of Polymer Mechanical Properties by Indentation”, Advanced Materials, vol. 21. pp. 3551-3561, 2009.
P. R. Monasterio, Lau, T. T., Yip, S., and Van Vliet, K. J., “Hydrogen-Vacancy Interactions in Fe-C Alloys”, Physical Review Letters, vol. 103. 2009.
D. J. Schmidt et al., “Electrochemically Controlled Swelling and Mechanical Properties of a Polymer Nanocomposite”, Acs Nano, vol. 3. pp. 2207-2216, 2009.
G. Constantinides, Tweedie, C. A., Savva, N., Smith, J. F., and Van Vliet, K. J., “Quantitative Impact Testing of Energy Dissipation at Surfaces”, Experimental Mechanics, vol. 49. pp. 511-522, 2009.
S. Buell, Van Vliet, K. J., and Rutledge, G. C., “Mechanical Properties of Glassy Polyethylene Nanofibers via Molecular Dynamics Simulations”, Macromolecules, vol. 42. pp. 4887-4895, 2009.
D. K. Hwang et al., “Stop-Flow Lithography for the Production of Shape-Evolving Degradable Microgel Particles”, Journal of the American Chemical Society, vol. 131. pp. 4499-4504, 2009.
V. V. Yashin, Van Vliet, K. J., and Balazs, A. C., “Controlling chemical oscillations in heterogeneous Belousov-Zhabotinsky gels via mechanical strain”, Physical Review E, vol. 79. 2009.
T. T. Lau, Lin, X., Yip, S., and Van Vliet, K. J., “Atomistic examination of the unit processes and vacancy-dislocation interaction in dislocation climb”, Scripta Materialia, vol. 60. pp. 399-402, 2009.
A. A. Chen, Khetani, S. R., Lee, S., Bhatia, S. N., and Van Vliet, K. J., “Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers”, Biomaterials, vol. 30. pp. 1113-1120, 2009.
J. M. Kranenburg et al., “Correlating the mechanical and surface properties with the composition of triblock copoly(2-oxazoline)s”, Journal of Materials Chemistry, vol. 19. pp. 222-229, 2009.
G. Constantinides, Kalcioglu, I., Smith, J. F., and Van Vliet, K. J., Nanoindentation in Fluid: A Pathway to Nanoscale Poromechanical Materials Characterization. 2009.

2008

G. Constantinides, Kalcioglu, I., McFarland, M., Smith, J. F., and Van Vliet, K. J., “Probing mechanical properties of fully hydrated gels and biological tissues”, Journal of Biomechanics, vol. 41. pp. 3285-3289, 2008.
J. M. Maloney, Walton, E. B., Bruce, C. M., and Van Vliet, K. J., “Influence of finite thickness and stiffness on cellular adhesion-induced deformation of compliant substrata”, Physical Review E, vol. 78. 2008.
J. A. Lichter, Thompson, T., Delga-Dillo, M., Nishikawa, T., Rubner, M. F., and Van Vliet, K. J., “Substrata Mechanical Stiffness Can Regulate Adhesion of Viable Bacteria (vol 9, pg 1571, 2008)”, Biomacromolecules, vol. 9. pp. 2967-2967, 2008.
R. Krishnan, Oommen, B., Walton, E. B., Maloney, J. M., and Van Vliet, K. J., “Modeling and simulation of chemomechanics at the cell-matrix interface”, Cell Adhesion & Migration, vol. 2. pp. 83-94, 2008.
J. A. Lichter, Thompson, T., Delgadillo, M., Nishikawa, T., Rubner, M. F., and Van Vliet, K. J., “Substrata mechanical stiffness can regulate adhesion of viable bacteria”, Biomacromolecules, vol. 9. pp. 1571-1578, 2008.
B. P. Kanungo, Silva, E. C. C. M., Van Vliet, K. J., and Gibson, L. J., “Characterization of mineralized collagen-glycosaminoglycan scaffolds for bone regeneration”, Acta Biomaterialia, vol. 4. pp. 490-503, 2008.
E. B. Walton, Lee, S., and Van Vliet, K. J., “Extending Bell's model: How force transducer stiffness alters measured unbinding forces and kinetics of molecular complexes”, Biophysical Journal, vol. 94. pp. 2621-2630, 2008.
K. J. Van Vliet, “Chemomechanics of complex materials: challenges and opportunities in predictive kinetic timescales”, Scientific Modeling and Simulations, vol. 15. pp. 67-80, 2008.

2007

S. Curgul, Van Vliet, K. J., and Rutledge, G. C., “Molecular dynamics simulation of size-dependent structural and thermal properties of polymer nanofibers”, Macromolecules, vol. 40. pp. 8483-8489, 2007.
C. A. Tweedie, Constantinides, G., Lehman, K. E., Brill, D. J., Blackman, G. S., and Van Vliet, K. J., “Enhanced stiffness of amorphous polymer surfaces under confinement of localized contact loads”, Advanced Materials, vol. 19. p. 2540 - +, 2007.
S. Curgul, Van Vliet, K. J., and Rutledge, G. C., “POLY 95-Structure and properties of polyethylene nanofibers from molecular dynamics simulations”, Abstracts of Papers of the American Chemical Society, vol. 234. 2007.
M. W. M. Fijten et al., “Synthesis and structure-property relationships of random and block copolymers: A direct comparison for copoly(2-oxazoline)s”, Macromolecules, vol. 40. pp. 5879-5886, 2007.
G. Constantinides, Silva, E. C. C. M., Blackman, G. S., and Van Vliet, K. J., “Dealing with imperfection: quantifying potential length scale artefacts from nominally spherical indenter probes”, Nanotechnology, vol. 18. 2007.
S. Lee, Mandic, J., and Van Vliet, K. J., “Chemomechanical mapping of ligand-receptor binding kinetics on cells”, Proceedings of the National Academy of Sciences of the United States of America, vol. 104. pp. 9609-9614, 2007.
T. T. Lau, Foerst, C. J., Lin, X., Gale, J. D., Yip, S., and Van Vliet, K. J., “Many-body potential for point defect clusters in Fe-C alloys”, Physical Review Letters, vol. 98. 2007.
C. -Y. Chiang, Mello, C. M., Gu, J., Silva, E. C. C. M., Van Vliet, K. J., and Belcher, A. M., “Weaving genetically engineered functionality into mechanically robust virus fibers”, Advanced Materials, vol. 19. p. 826 - +, 2007.
T. F. Juliano, VanLandingham, M. R., Tweedie, C. A., and Van Vliet, K. J., “Multiscale creep compliance of epoxy networks at elevated temperatures”, Experimental Mechanics, vol. 47. pp. 99-105, 2007.
S. Lee and Van Vliet, K. J., “Seeing by feeling: Kinetics of ligand-receptor binding through force-based imaging of cell surfaces”, Biophysical Journal. p. 527A - 527A, 2007.
M. Notomi, Van Vliet, K. J., and Yip, S., “Classification and characterization of the shape memory binary alloys”, in Advanced Intermetallic-Based Alloys, vol. 980, 2007, pp. 223-228.
J. M. Kranenburg et al., “Elastic moduli for a diblock copoly(2-oxazoline) library obtained by high-throughput screening”, Journal of Materials Chemistry, vol. 17. pp. 2713-2721, 2007.
E. B. Walton, Oommen, B., and Van Vliet, K. J., “How stiff and thin can an engineered extracellular matrix be? Modeling molecular forces at the cell-matrix interface”, in 2007 Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-16, 2007, pp. 6419-6421.
E. Walton and Van Vliet, K. J., “Beyond Bell's Theorem: Reconciling theory, modeling, and experimental measurement of ligand-receptor unbinding forces”, Biophysical Journal. p. 528A - 528A, 2007.

2006

E. B. Walton and Van Vliet, K. J., “Equilibration of experimentally determined protein structures for molecular dynamics simulation”, Physical Review E, vol. 74. 2006.
C. A. Tweedie and Van Vliet, K. J., “On the indentation recovery and fleeting hardness of polymers”, Journal of Materials Research, vol. 21. pp. 3029-3036, 2006.
E. C. C. M. Silva and Van Vliet, K. J., “Robust approach to maximize the range and accuracy of force application in atomic force microscopes with nonlinear position-sensitive detectors”, Nanotechnology, vol. 17. pp. 5525-5530, 2006.
D. G. Anderson et al., “A combinatorial library of photocrosslinkable and degradable materials”, Advanced Materials, vol. 18. p. 2614 - +, 2006.
G. Constantinides, Chandran, K. S. R., Ulm, F. -J., and Van Vliet, K. J., “Grid indentation analysis of composite microstructure and mechanics: Principles and validation”, Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing, vol. 430. pp. 189-202, 2006.
B. Oommen and Van Vliet, K. J., “Effects of nanoscale thickness and elastic nonlinearity on measured mechanical properties of polymeric films”, Thin Solid Films, vol. 513. pp. 235-242, 2006.
K. J. Van Vliet and Hinterdorfer, P., “Probing drug-cell interactions”, Nano Today, vol. 1. pp. 18-25, 2006.
M. T. Thompson, Berg, M. C., Tobias, I. S., Lichter, J. A., Rubner, M. F., and Van Vliet, K. J., “Biochemical functionalization of polymeric cell substrata can alter mechanical compliance”, Biomacromolecules, vol. 7. pp. 1990-1995, 2006.
C. A. Tweedie and Van Vliet, K. J., “Contact creep compliance of viscoelastic materials via nanoindentation”, Journal of Materials Research, vol. 21. pp. 1576-1589, 2006.
C. J. Forst, Slycke, J., Van Vliet, K. J., and Yip, S., “Point defect concentrations in metastable Fe-C alloys”, Physical Review Letters, vol. 96. 2006.
E. C. C. M. Silva, Tong, L. M., Yip, S., and Van Vliet, K. J., “Size effects on the stiffness of silica nanowires”, Small, vol. 2. pp. 239-243, 2006.

2005

M. T. Thompson, Berg, M. C., Tobias, I. S., Rubner, M. F., and Van Vliet, K. J., “Tuning compliance of nanoscale polyelectrolyte multilayers to modulate cell adhesion”, Biomaterials, vol. 26. pp. 6836-6845, 2005.
C. A. Tweedie, Anderson, D. G., Langer, R., and Van Vliet, K. J., “Combinatorial material mechanics: High-throughput polymer synthesis and nanomechanical screening”, Advanced Materials, vol. 17. p. 2599 - +, 2005.
J. M. Young and Van Vliet, K. J., “Predicting in vivo failure of pseudoelastic NiTi devices under low cycle, high amplitude fatigue”, Journal of Biomedical Materials Research Part B-Applied Biomaterials, vol. 72B. pp. 17-26, 2005.
C. A. Tweedie, Smith, J. F., and Van Vliet, K. J., “Nanomechanical quantification of polymer energy absorption”, in Fundamentals of Nanoindentation and Nanotribology III, vol. 841, 2005, pp. 205-210.

2004

A. Shukla, Dunn, A. R., Moses, M. A., and Van Vliet, K. J., “Endothelial cells as mechanical transducers: enzymatic activity and network formation under cyclic strain.”, Mechanics & chemistry of biosystems : MCB, vol. 1. pp. 279-90, 2004.
T. Zhu, Li, J., Van Vliet, K. J., Ogata, S., Yip, S., and Suresh, S., “Predictive modeling of nanoindentation-induced homogeneous dislocation nucleation in copper”, Journal of the Mechanics and Physics of Solids, vol. 52. pp. 691-724, 2004.
J. Li, Zhu, T., Yip, S., Van Vliet, K. J., and Suresh, S., “Elastic criterion for dislocation nucleation”, Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing, vol. 365. pp. 25-30, 2004.
K. J. Van Vliet, Prchlik, L., and Smith, J. F., “Direct measurement of indentation frame compliance”, Journal of Materials Research, vol. 19. pp. 325-331, 2004.
K. J. Van Vliet, Li, J., Zhu, T., Choi, Y. J., Yip, S., and Suresh, S., Defect nucleation - Predictions through nanoscale experiments and computations, vol. 115. 2004.

2003

K. J. Van Vliet, Bao, G., and Suresh, S., “The biomechanics toolbox: experimental approaches for living cells and biomolecules”, Acta Materialia, vol. 51. pp. 5881-5905, 2003.
Y. Choi, Van Vliet, K. J., Li, J., and Suresh, S., “Size effects on the onset of plastic deformation during nanoindentation of thin films and patterned lines”, Journal of Applied Physics, vol. 94. pp. 6050-6058, 2003.
K. J. Van Vliet, Tsikata, S., and Suresh, S., “Model experiments for direct visualization of grain boundary deformation in nanocrystalline metals”, Applied Physics Letters, vol. 83. pp. 1441-1443, 2003.
G. Constantinides, Ulm, F., and Van Vliet, K. J., “On the use of nanoindentation for cementitious materials”, Materials and Structures, vol. 36. pp. 191-196, 2003.
K. J. Van Vliet, Li, J., Zhu, T., Yip, S., and Suresh, S., “Quantifying the early stages of plasticity through nanoscale experiments and simulations”, Physical Review B, vol. 67. 2003.
T. Zhu, Li, J., Van Vliet, K. J., Yip, S., and Suresh, S., Simulation of nanoindentation via interatomic potential finite element method. 2003.

2002

J. Li, Van Vliet, K. J., Zhu, T., Yip, S., and Suresh, S., “Atomistic mechanisms governing elastic limit and incipient plasticity in crystals”, Nature, vol. 418. pp. 307-310, 2002.
K. J. Van Vliet and Suresh, S., “Simulations of cyclic normal indentation of crystal surfaces using the bubble-raft model”, Philosophical Magazine a-Physics of Condensed Matter Structure Defects and Mechanical Properties, vol. 82. pp. 1993-2001, 2002.

2001

M. Dao, Chollacoop, N., Van Vliet, K. J., Venkatesh, T. A., and Suresh, S., “Computational modeling of the forward and reverse problems in instrumented sharp indentation”, Acta Materialia, vol. 49. pp. 3899-3918, 2001.
A. Gouldstone, Van Vliet, K. J., and Suresh, S., “Nanoindentation - Simulation of defect nucleation in a crystal”, Nature, vol. 411. pp. 656-656, 2001.
K. J. Van Vliet and Gouldstone, A., “First prize - Mechanical properties of thin films quantified via instrumented indentation”, Surface Engineering, vol. 17. pp. 140-145, 2001.

2000

T. A. Venkatesh, Van Vliet, K. J., Giannakopoulos, A. E., and Suresh, S., “Determination of elasto-plastic properties by instrumented sharp indentation: Guidelines for property extraction”, Scripta Materialia, vol. 42. pp. 833-839, 2000.