Publications

Found 186 results
Filters: Author is Darrell J. Irvine  [Clear All Filters]
2016
J. M. Steichen, Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., Garces, F., Freund, N. T., Gitlin, A. D., Menis, S., Georgeson, E., Kubitz, M., Adachi, Y., Jones, M., Mutafyan, A. A., Yun, D. Soo, Mayer, C. T., Ward, A. B., Burton, D. R., Wilson, I. A., Irvine, D. J., Nussenzweig, M. C., and Schief, W. R., HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies, Immunity, vol. 45, no. 3, pp. 483 - 496, 2016.
D. J. Irvine, Materializing the future of vaccines and immunotherapy, Nature Reviews Materials, vol. 1, no. 1, p. 15008, 2016.
R. J. Kimmerling, Szeto, G. Lee, Li, J. W., Genshaft, A. S., Kazer, S. W., Payer, K. R., Borrajo, Jde Riba, Irvine, D. J., Shalek, A. K., and Manalis, S. R., A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages, Nature Communications, vol. 7, p. 10220, 2016.
D. J. Irvine, A Receptor for All Occasions, Cell, vol. 164, no. 4, pp. 599 - 600, 2016.
S. Kumari, Poh, Y., Melo, M., Mak, M., Vasile, E., Kamm, R., Geha, R., and Irvine, D. J., Specialized actin architecture mechanically tunes T cell synaptic contact lifetime., Molecular Biology of the Cell, vol. 27, 2016.
B. R. Jones, Mueller, S., O'Connor, R., Rimpel, K., Sloan, D. D., Karel, D., Wong, H. C., Jeng, E. K., Thomas, A. S., Whitney, J. B., Lim, S. - Y., Kovacs, C., Benko, E., Karandish, S., Huang, S. - H., Buzon, M. J., Lichterfeld, M., Irrinki, A., Murry, J. P., Tsai, A., Yu, H., Geleziunas, R., Trocha, A., Ostrowski, M. A., Irvine, D. J., and Walker, B. D., A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4(+) T-Cells to Recognition by Cytotoxic T-Lymphocytes, Plos Pathogens, vol. 12, no. 4, p. e1005545, 2016.
H. Hei Tam, Melo, M. B., Kang, M., Pelet, J. M., Ruda, V. M., Foley, M. H., Hu, J. K., Kumari, S., Crampton, J., Baldeon, A. D., Sanders, R. W., Moore, J. P., Crotty, S., Langer, R., Anderson, D. G., Chakraborty, A. K., and Irvine, D. J., Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 43, pp. E6639 - E6648, 2016.
K. L. Griffiths, Ahmed, M., Das, S., Gopal, R., Horne, W., Connell, T. D., Moynihan, K. D., Kolls, J. K., Irvine, D. J., Artyomov, M. N., Rangel-Moreno, J., and Khader, S. A., Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy, Nature Communications, vol. 7, p. 13894, 2016.
A. Tzeng, Kauke, M. J., Zhu, E. F., Moynihan, K. D., Opel, C. F., Yang, N. J., Mehta, N., Kelly, R. L., Szeto, G. L., Overwijk, W. W., Irvine, D. J., and K. Wittrup, D., Temporally Programmed CD8 alpha(+) DC Activation Enhances Combination Cancer Immunotherapy, Cell Reports, vol. 17, no. 10, pp. 2503 - 2511, 2016.
2015
B. Huang, Abraham, W. D., Zheng, Y., Lopez, S. C. Bustama, Luo, S. S., and Irvine, D. J., Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells, Science Translational Medicine, vol. 7, no. 291, p. 291ra94, 2015.
E. L. Dane and Irvine, D. J., Big thinking for adjuvants, Nature Biotechnology, vol. 33, no. 11, pp. 1146 - 1148, 2015.
N. A. Hotaling, Tang, L., Irvine, D. J., and Babensee, J. E., Biomaterial Strategies for Immunomodulation, in Annual Review of Biomedical Engineering, Vol 17, vol. 17, M. L. Yarmush 2015, pp. 317 - 349.
K. B. Arnold, Szeto, G. L., Alter, G., Irvine, D. J., and Lauffenburger, D. A., CD4(+) T cell-dependent and CD4(+) T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals, Science Signaling, vol. 8, no. 399, p. ra104, 2015.
H. Liu and Irvine, D. J., Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications, Bioconjugate Chemistry, vol. 26, no. 5, pp. 791 - 801, 2015.
S. B. Kudchodkar, Tang, L., Jeng, E. K., Wong, H. C., Irvine, D. J., and Maus, M. V., Improving CAR T Cell Efficacy for Solid Tumors By Nanogel-Based Delivery of Immunomodulatory Proteins, Molecular Therapy, vol. 23, pp. S207 - S207, 2015.
P. U. Atukorale, Yang, Y. - S., Bekdemir, A., Carney, R. P., Silva, P. J., Watson, N., Stellacci, F., and Irvine, D. J., Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes, Nanoscale, vol. 7, no. 26, pp. 11420 - 11432, 2015.
P. U. Atukorale, Yang, Y. - S., Bekdemir, A., Carney, R. P., Silva, P. J., Watson, N., Stellacci, F., and Irvine, D. J., Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes, Nanoscale, vol. 7, no. 26, pp. 11420 - 11432, 2015.
M. C. Hanson, Abraham, W., Crespo, M. P., Chen, S. H., Liu, H., Szeto, G. Lee, Kim, M., Reinherz, E. L., and Irvine, D. J., Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides, Vaccine, vol. 33, no. 7, pp. 861 - 868, 2015.
S. Wang, Mata-Fink, J., Kriegsman, B., Hanson, M., Irvine, D. J., Eisen, H. N., Burton, D. R., K. Wittrup, D., Kardar, M., and Chakraborty, A. K., Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies, Cell, vol. 160, no. 4, pp. 785 - 797, 2015.
S. Wang, Mata-Fink, J., Kriegsman, B., Hanson, M., Irvine, D. J., Eisen, H. N., Burton, D. R., K. Wittrup, D., Kardar, M., and Chakraborty, A. K., Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies, Cell, vol. 160, no. 4, pp. 785 - 797, 2015.
G. Lee Szeto, Van Egeren, D., Worku, H., Sharei, A., Alejandro, B., Park, C., Frew, K., Brefo, M., Mao, S., Heimann, M., Langer, R., Jensen, K. F., and Irvine, D. J., Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines, Scientific Reports, vol. 5, p. 10276, 2015.
M. C. Hanson, Crespo, M. R., Abraham, W., Moynihan, K. D., Szeto, G. L., Chen, S. H., Melo, M. B., Mueller, S., and Irvine, D. J., Nanoparticu late STING agonists are potent lymph node-targeted vaccine adjuvants, Journal of Clinical Investigation, vol. 125, no. 6, pp. 2532 - 2546, 2015.
M. Castellarnau, Szeto, G. L., Su, H. - W., Tokatlian, T., Love, J. C., Irvine, D. J., and Voldman, J., Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis, Small, vol. 11, no. 4, pp. 489 - 498, 2015.
M. Castellarnau, Szeto, G. L., Su, H. - W., Tokatlian, T., Love, J. C., Irvine, D. J., and Voldman, J., Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis, Small, vol. 11, no. 4, pp. 489 - 498, 2015.
E. F. Zhu, Gai, S. A., Opel, C. F., Kwan, B. H., Surana, R., Mihm, M. C., Kauke, M. J., Moynihan, K. D., Angelini, A., Williams, R. T., Stephan, M. T., Kim, J. S., Yaffe, M. B., Irvine, D. J., Weiner, L. M., Dranoff, G., and K. Wittrup, D., Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2, Cancer Cell, vol. 27, no. 4, pp. 489 - 501, 2015.

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