Von Willlebrand Adhesion to Surfaces at High Shear Rates Is Controlled by Long-Lived Bonds

TitleVon Willlebrand Adhesion to Surfaces at High Shear Rates Is Controlled by Long-Lived Bonds
Publication TypeJournal Article
Year of Publication2013
AuthorsSing, CE, Selvidge, JG, Alexander-Katz, A
JournalBiophysical Journal
Volume105
Issue6
Pagination1475 - 1481
Date Published2013/09/17/
Abstract

Von Willebrand factor (vWF) adsorbs and immobilizes platelets at sites of injury under high-shear-rate conditions. It has been recently demonstrated that single vWF molecules only adsorb significantly to collagen above a threshold shear, and here we explain such counterintuitive behavior using a coarse-grained simulation and a phenomenological theory. We find that shear-induced adsorption only occurs if the vWF-surface bonds are slip-resistant such that force-induced unbinding is suppressed, which occurs in many biological bonds (i.e., catch bonds). Our results quantitatively match experimental observations and may be important to understand the activation and mechanical regulation of vWF activity during blood clotting.