Subcellular Electrode Arrays for Multisite Recording of Dopamine in Vivo

TitleSubcellular Electrode Arrays for Multisite Recording of Dopamine in Vivo
Publication TypeBook Chapter
Year of Publication2017
AuthorsSchwerdt, HN, Kim, M, Karasan, E, Amemori, S, Homma, D, Shimazu, H, Yoshida, T, Langer, R, Graybiel, AM, Cima, MJ
Book Title30th Ieee International Conference on Micro Electro Mechanical Systems (mems 2017)
Pagination549 - 552
PublisherIeee
CityNew York
ISBN Number978-1-5090-5078-9
Abstract

We report the fabrication and use of carbon fiber (CF) arrays with 8 recording electrodes having individual diameters of 8 - 10 mu m (9 - 10 times smaller than conventional sensors and state of art) for electrochemical recording of dopamine from deep brain regions in a minimally invasive and high density manner. Accordingly, key advancements demonstrated are (1) radical reduction in size and (2) potential for wide spatial distribution of concurrent electrochemical measurement in the brain.