Simultaneous solvent screening and reaction optimization in microliter slugs

TitleSimultaneous solvent screening and reaction optimization in microliter slugs
Publication TypeJournal Article
Year of Publication2015
AuthorsReizman, BJ, Jensen, KF
JournalChemical Communications
Volume51
Issue68
Pagination13290 - 13293
Date Published2015///
Abstract

An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 mu L droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.