|Title||A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Hwang, Y-J, Coley, CW, Abolhasani, M, Marzinzik, AL, Koch, G, Spanka, C, Lehmann, H, Jensen, KF|
|Pagination||6649 - 6652|
|Keywords||active pharmaceutical ingredients, candidates, drug discovery, generation, inhibitors, systems|
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 mu L. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.
|Short Title||Chem. Commun.|