A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

TitleA segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets
Publication TypeJournal Article
Year of Publication2017
AuthorsHwang, Y-J, Coley, CW, Abolhasani, M, Marzinzik, AL, Koch, G, Spanka, C, Lehmann, H, Jensen, KF
JournalChemical Communications
Volume53
Issue49
Pagination6649 - 6652
Date Published2017/06/21/
ISBN Number1359-7345
Keywordsactive pharmaceutical ingredients, candidates, drug discovery, generation, inhibitors, systems
Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 mu L. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Short TitleChem. Commun.