A Receptor for All Occasions

TitleA Receptor for All Occasions
Publication TypeJournal Article
Year of Publication2016
AuthorsIrvine, DJ
JournalCell
Volume164
Issue4
Pagination599 - 600
Date Published2016/02/11/
ISBN Number0092-8674
KeywordsImmunotherapy, notch
Abstract

Cells communicate with their environment, in part, through cell surface receptors. Engineering receptors that both sense arbitrary inputs and provide outputs orthogonal to endogenous signaling pathways has been a challenge. Now, Lim and colleagues report a system based on synthetic Notch receptors that allows independent control of both inputs and outputs in diverse cell types.

Short TitleCell