Delivering safer immunotherapies for cancer

TitleDelivering safer immunotherapies for cancer
Publication TypeJournal Article
Year of Publication2017
AuthorsMilling, L, Zhang, Y, Irvine, DJ
JournalAdvanced Drug Delivery Reviews
Volume114
Pagination79 - 101
Date Published2017/05/15/
ISBN Number0169-409X
KeywordsAdoptive cell therapy, b16 melanoma tumors, cancer immunotherapy, Checkpoint blockade, in-situ vaccination, metastatic breast-cancer, monoclonal-antibody tgn1412, Nanoparticles, nivolumab plus ipilimumab, peripheral-blood lymphocytes, regulatory t-cells, tumor-necrosis-factor, vascular endothelial-cells, walled carbon nanotubes
Abstract

Cancer immunotherapy is now a powerful clinical reality, with a steady progression of new drug approvals and a massive pipeline of additional treatments in clinical and preclinical development. However, modulation of the immune system can be a double-edged sword: Drugs that activate immune effectors are prone to serious nonspecific systemic inflammation and autoimmune side effects. Drug delivery technologies have an important role to play in harnessing the power of immune therapeutics while avoiding on-target/off-tumor toxicities. Here we review mechanisms of toxicity for clinically-relevant immunotherapeutics, and discuss approaches based in drug delivery technology to enhance the safety and potency of these treatments. These include strategies to merge drug delivery with adoptive cellular therapies, targeting immunotherapies to tumors or select immune cells, and localizing therapeutics intratumorally. Rational design employing lessons learned from the drug delivery and nanomedicine fields has the potential to facilitate immunotherapy reaching its full potential. (C) 2017 The Authors. Published by Elsevier B.V.

Short TitleAdv. Drug Deliv. Rev.