Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

TitleContinuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability
Publication TypeJournal Article
Year of Publication2018
AuthorsImbrogno, J, Rogers, L, Thomas, DA, Jensen, KF
JournalChemical Communications
Volume54
Issue1
Pagination70 - 73
Date Published2018/01/04/
ISBN Number1359-7345
Keywordscontinuous-flow synthesis, liquid-liquid-extraction, separation, slug flow
Abstract

Continuous processing of pharmaceuticals opens opportunities for continuous separation based on wettability of polymer membranes. Dual use of hydrophobic and hydrophilic membranes realize in-line liquid-liquid extraction in the synthesis of four essential APIs. A secondary membrane with opposite wetting characteristics proves critical to phase separation of aqueous-organic reaction streams.

Short TitleChem. Commun.