Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

TitleEffect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
Publication TypeJournal Article
Year of Publication2013
AuthorsVan Lehn, RC, Atukorale, PU, Carney, RP, Yang, Y-S, Stellacci, F, Irvine, DJ, Alexander-Katz, A
JournalNano Letters
Volume13
Issue9
Pagination4060 - 4067
Date Published2013/09//
Abstract

Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.