Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications

TitleGuiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications
Publication TypeJournal Article
Year of Publication2015
AuthorsLiu, H, Irvine, DJ
JournalBioconjugate Chemistry
Volume26
Issue5
Pagination791 - 801
Date Published2015/05//
Abstract

Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.