Lunch and Lecture, April 14, Prof. Darrell Irvine

April 11, 2010

Combining cell therapy and nanoparticle drug delivery: Chemical cell surface engineering on live cells using nanoparticles
Darrell J. Irvine, Associate Professor of Materials Science and Engineering & Biological Engineering
Wednesday, April 14
12:00pm-1:00pm (pizza and refreshments will be served at 11:40am)
The Chipman Room (6-104)
Cell therapies are of interest for treatment of a broad range of conditions, from liver disease to cancer. To enhance cell therapy, we developed a generic strategy utilizing endogenous free thiols at the surfaces of cells to conjugate drug-loaded nanoparticles (including liposomes or biodegradable polymer particles) to the surfaces of live cells, enabling therapeutic cells to act as living vectors for transport of nanoparticle (NP) drug carriers into target tissues in vivo. In the setting of cancer therapy, particles (100-200 nm diam.) conjugated to CD8+ T-cells were not endocytosed and did not block normal T-cell functions. We found T-cell-mediated NP delivery reduced liver/spleen clearance of NP drug carriers and dramatically increased the accumulation of NPs in tumors by up to 500-1000-fold, compared to i.v. injected “free” NPs. This approach provides a new strategy for achieving truly targeted drug delivery in vivo and may enable adoptive cell therapy to effectively eliminate disseminated cancer.
*The MRS "Lunch N Lecture" is a series of informal talks from any faculty member whose research interests are in materials. To learn more about the MIT MRS chapter and its lecture series, please visit the homepage. Want to see a particular faculty member give a talk? E-mail the MRS officers and give us suggestions!
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