Internal Friction and Nonequilibrium Unfolding of Polymeric Globules

TitleInternal Friction and Nonequilibrium Unfolding of Polymeric Globules
Publication TypeJournal Article
Year of Publication2009
AuthorsAlexander-Katz, A, Wada, H, Netz, RR
JournalPhysical Review Letters
Volume103
Issue2
Date Published2009/07/10/
Abstract

The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive strength between monomers. These results explain friction effects of globular DNA and are relevant for dissipation at intermediate stages of protein folding.