Krystyn J. Van Vliet
Paul M. Cook Career Development Associate Professor of Materials Science and Engineering
ScB, Materials Engineering, Brown University, 1998
PhD, Materials Engineering, MIT, 2002
Room 8-237, 77 Mass. Ave., Cambridge, MA 02139
Professor Van Vliet's group studies material chemomechanics: material behavior at the interface of mechanics, chemistry, physics, and biology. She focuses on thermodynamically metastable surfaces and interfaces, in which stress-assisted chemical reaction kinetics are notoriously difficult to analyze via either experiment or simulation. The mechanisms of this coupling in cell-material interactions are incompletely understood, due to both biological complexity and lack of appropriate experimental and computational tools, but are key to design of materials that modulate cell adhesion for drug uptake and differentiation. Her long-term goal is to predict and modulate key functions of biological cells by drawing analogies to the coupled chemical/mechanical behavior of structurally simpler, nonbiological material interfaces and nanocomposites. These integrated experimental and computational efforts include three main thrusts: (1) chemomechanical mapping of nanocomposite surfaces including living cells; (2) mechanics of amorphous and viscoelastic surfaces and nanostructures; and (3) chemical kinetics in mechanically strained, nanoscale material interfaces. Her group has used this interdisciplinary application of mechanical and chemical forces to rapidly map environment-structure-property relations in engineered materials, and to predict the binding kinetics of individual molecules on living cells. These studies have shown that the stiffness of materials to which molecular ligands are tethered can directly affect kinetics of ligand-receptor interactions at cell surfaces.
Professor Van Vliet serves as the faculty supervisor of the DMSE Nanomechanical Technology Laboratory, has co-developed new undergraduate core classes, and has implemented new programs to retain underrepresented minority students.
Walton, E.B., Lee, S., and Van Vliet, K.J. "Extending Bell's model: how force transducer stiffness affects measured unbinding force and kinetics of molecular complexes." Biophysical Journal 94 2621–2630 (2008).
Lichter, J., Thompson, M.T., Delgadillo, M., Rubner, M.F., and Van Vliet, K.J. "Substrata mechanical stiffness can regulate adhesion of viable bacteria." Biomacromolecules 9 1571–1578 (2008).
Krishnan, R., Oommen, B., Walton, E.B., Maloney, J.M., and Van Vliet, K.J. "Modeling and simulation of chemomechanics at the cell-matrix interface." Cell Adhesion and Migration 2 13–24 (2008).
Maloney, J., Walton, E., Bruce, C., and Van Vliet, K.J. "Influence of finite thickness and stiffness on cellular adhesion-induced deformation of compliant substrata." Physical Review E 78: 041923 (2008).
Constantinides, G., Kalcioglu, I., McFarland, M., Smith, J., and Van Vliet, K.J. " Probing mechanical properties of fully hydrated gels and biological tissues." Journal of Biomechanics 41:3285–3289 (2008).
"Chemomechanical Mapping of Ligand-Receptor Binding Kinetics on Cells," Proceedings of the National Academy of Sciences, 104: 9609–9614 (2007) (with others).
MIT News Office profiles Prof. Van Vliet
Exploring the inner workings of materials: From concrete to cancer cells, Van Vliet brings an engineer’s mindset to the study of biology and materials.
|November 2, 2011|
The Concrete Sustainability Hub was founded at MIT in 2009; the
|October 14, 2011|
|Prof. Krystyn Van Vliet and Chemomechanical Interactions at the Nanoscale||September 21, 2011|
|A new approach to scratch resistance||August 17, 2011|
DMSE Faculty use new methods to understand old materials
A computational approach to materials science and engineering could bring new properties even to familiar substances such as concrete and steel.
|October 28, 2009|