Faculty

Darrell J. Irvine

 

Disciplines

Research

The Irvine laboratory works at the interface of materials science and immunology. Synthetic materials can be applied in two major ways to 'immunobioengineering': (1) Synthetic materials can modulate the function of immune cells by mimicking signals derived from the immune system or foreign pathogens, both as a probe for cell function and as a tool for immunotherapy— both in vitro and in vivo; (2) Synthetic materials can be used to create in vitro and in vivo models of the microenvironment present in lymphoid and non-lymphoid tissues, to better understand immunobiology in health and disease. To meet these goals, engineering must be married to an in-depth appreciation for the biology of these problems. Their laboratory is thus deeply interdisciplinary in every project. Key to their approach is a balanced emphasis on both the engineering and immunological aspects of the problems the Irvine group has chosen to address: In each of these projects, state of the art chemistry, polymer science, physics and immunology are combined to address critical biological questions and medical challenges.

Selected Publications

Hori Y, Winans AM, Huang CC, Horrigan EM, and Irvine DJ, “Injectable dendritic cell-carrying alginate gels for immunization and immunotherapy,” Biomaterials 29 3671–3682 (2008).

Verma A, Uzun O, Hu Y, Watson N, Chen S, Irvine DJ, and Stellacci F, “Cell penetrating nanoparticles: the role of ligand shell structure,” Nature Materials, 7 588–595 (2008).

Hu Y, Litwin T, Nagaraja AR, Kwong B, Katz J, Watson N, and Irvine DJ, “Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles,” Nano Letters 7(10) 3056–3064 (2007).

Stachowiak AN and Irvine DJ, “Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration,” Journal of Biomedical Materials Research A, published online Oct. 15, 2007.

Doh J, and Irvine DJ, “Immunological Synapse Arrays: Patterned Protein Surfaces that Template Immunological Synapse Structure Formation in T Cells,” Proceedings of the National Academy of Sciences, U.S.A., 103(15) 5700–5705 (2006). Pubmed Central ID: 1458636

Zhao X, Jain S, Larman HB, Gonzalez S, and Irvine DJ, “Directed cell migration via chemoattractants released from degradable microspheres,” Biomaterials, 26(24) 5048–5063 (2005).

Related News

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February 18, 2014
Nanoparticle vaccine offers better protection
Particles that deliver vaccines directly to mucosal surfaces could defend against many infectious diseases.
September 26, 2013
Polymer films used in vaccinations
A polymer film that gradually releases DNA coding for viral proteins could offer a better alternative to traditional vaccines;  Professor Darrell Irvine and his collaborators are working on just su
January 28, 2013
Prof. Irvine and colleagues are working on an AIDS vaccine
Prof. Darrell Irvine and colleagues Darrell Irvine have received funding to break down silos of scientific disciplines to create an AIDS vaccine.
October 19, 2012
Faculty Updates
Please join us in welcoming Professor Antoine Allanore and Professor Niels Holten-And
June 29, 2012
TechTV goes Inside the lab: Darrell J. Irvine, Ph.D.
October 20, 2011
Lunch and Lecture, April 14, Prof. Darrell Irvine
Combining cell therapy and nanoparticle drug delivery: Chemical cell surface engineering on live cells using nanoparticles
April 12, 2010
Prof. Irvine presents lecture for Koch Institute for Cancer Research December 11, 2009
Prof. Irvine profiled in Spectrum
Spectrum, a magazine from the MIT Office of Resource Development, profiled Prof. Darrell J.
October 2, 2009