Faculty

Michael J. Cima

 

Disciplines

Research

Prof. Cima is author or co-author of over two hundred peer-reviewed scientific publications and forty-five patents, and is a recognized expert in the field of materials processing. Prof. Cima is actively involved in materials and engineered systems aimed at improving human health such as treatments for cancer, metabolic diseases, trauma, and urological disorders. Prof. Cima's research includes advanced forming technologies for complex macro and micro devices, such as colloid science, MEMS and other micro components for medical devices that are used for drug delivery and diagnostics, as well as high-throughput development methods for formulations of materials and pharmaceutical formulations. He is a coinventor of MIT's three-dimensional printing process. His research has led to the development of chemically derived epitaxial oxide films for HTSC coated conductors. He and collaborators are developing implantable MEMS devices for unprecedented control in the delivery of pharmaceuticals and implantable diagnostic systems.

Selected Publications

Brown, K. A., Vassiliou, C. C., Issadore, D., Berezovsky, J., Cima, M. J. & Westervelt, R. M., “Scaling of transverse nuclear magnetic relaxation due to magnetic nanoparticle aggregation.” Journal of Magnetism and Magnetic Materials, 322, 3122–3126 (2010).

Elman, N. M., Daniel, K., Jalali-Yazdi, F. & Cima, M. J. “Super permeable nano-channel membranes defined with laser interferometric lithography”. Microfluidics and Nanofluidics 8, 557–563 (2010).

Lee, H. & Cima, M. J. “An intravesical device for the sustained delivery of lidocaine to the bladder”. Journal of Controlled Release (2010).

Ling, Y., Vassiliou, C. C. & Cima, M. J. “Magnetic relaxation-based platform for multiplexed assays”. Analyst 135, 2360–2364 (2010).

Tobias, I. S., Lee, H., Engelmayr, G. C., Macaya, D. ,Bettinger, C. J.& Cima, M. J. “Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device”. Journal of Controlled Release 146, 356–362 (2010).

Scott, A. W., Tyler, B. M., Masi, B. C., Upadhyay, U. M., Patta, Y. R., Grossman, R., Basaldella, L., Langer, R. S., Brem, H. & Cima, M. J., “Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model”. Biomaterials 32 (10), pp. 2532–2539 (2011)

Ling, Y., Pong, T., Vassiliou, C.C., Huang, P.L., Cima, M.J., “Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers.” Nature Biotechnology (in press) (2011).

Related News

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November 17, 2014
Better chemotherapy through targeted delivery
Every year, about 100,000 Americans are diagnosed with brain tumors that have spread from elsewhere in the body.
October 27, 2014
Shape-memory materials used to treat disease
The millions of people worldwide who suffer from the painful bladder disease known as interstitial cystitis (IC) may soon have a better, long-term treatment option, thanks to a controlled-release,
October 16, 2014
Pharmacy on a chip
CNN spotlighted MicroCHIPS, a company working on implantable devices
April 25, 2014
edX continues to add new subjects
The MIT News Office covers the latest additions to MITx; in the article, Professor Cima explains how
May 6, 2013
New techniques to diagnose and treat disease
With the recent launch of the Institute for
March 11, 2013
Science of Innovation: 3-D Printing
NBC visited MIT to film demonstrations of 3-D Printing and interview Professor Michael Cima.
February 13, 2013
3.091 to be offered as part of MITx
This spring, MIT launched an online learning collaboration, edX, that will allow anyone, anywhere with an internet connection to take classes aimed at a college audience, for personal or profession
July 24, 2012
New developments in wireless drug-delivery systems
Professor Michael Cima and his collaborators have reported successful human tests for first wirelessly controlled drug-delivery chip and announced that a clinical trial of the programmable, implant
February 17, 2012