Michael J. Cima

Sumitomo Electric Industries Professor of Engineering

BS Chemistry, University of California at Berkeley, 1982
PhD Chemical Engineering, University of California at Berkeley, 1986

Room 12-011, 77 Mass. Ave., Cambridge, MA  02139
617-253-6877 (phone)  617-258-6936 (fax)
mjcima@mit.edu

Prof. Cima is author or co-author of over one hundred and ninety peer-reviewed scientific publications and forty-five patents, and is a recognized expert in the field of materials processing. Prof. Cima is actively involved in materials and engineered systems aimed at improving human health such as treatments for cancer, metabolic diseases, trauma, and urological disorders. Prof. Cima's research includes advanced forming technologies for complex macro and micro devices, such as colloid science, MEMS and other micro components for medical devices that are used for drug delivery and diagnostics, as well as high-throughput development methods for formulations of materials and pharmaceutical formulations. He is a coinventor of MIT's three-dimensional printing process. His research has led to the development of chemically derived epitaxial oxide films for HTSC coated conductors. He and collaborators are developing implantable MEMS devices for unprecedented control in the delivery of pharmaceuticals and implantable diagnostic systems.

Selected Publications

Daniel KD, Kim GY, Vassiliou CC, Jalali-Yazdi F, Langer R, Cima M, "Multi-reservoir device for detecting a soluble cancer biomarker," Lab on a Chip 2007, 7, 1288–1293.

Kim GY , Cima MJ, "Magnetic Relaxation Switch Detection of Human Chorionic Gonadotrophin." Bioconjugate Chemistry 2007, (In Press).

Kim GY, Cima MJ, "Resorbable Polymer Microchips Releasing BCNU Inhibit Tumor Growth in the Rat 9L Flank Model." Journal of Controlled Release 2007 (In Press).

Staples M, Daniel K, Cima MJ, Langer R, "Application of Micro- and Nano-Electromechanical Devices to Drug Delivery." Pharmaceutical Research 2006, 23(5), 847–863.

Wesolowski, D.E., Yoshizumi, M., and Cima, M.J., "Trajectory-property Relationships in MOD-Derived YBCO Films." Physica C 2006, 450, 76–82.

Bullard, Joseph W.; Cima, Michael J. "Orientation Dependence of the Isoelectric Point of TiO2 (Rutile) Surfaces." Langmuir 2006, 22(24), 10264–10271.

In spring 2008, Prof. Cima's work in cancer treatment and detection garnered media in the Boston Sunday Globe (April 20, 2008) and WBUR's Here and Now (May 21, 2008).

His work on using nanoparticles in earlier detection of cancer was reported in the Oct. 31, 2005 Boston Globe. In Dec. 2006, the MIT News Office released a story on Prof. Cima's work in developing an implant that may assist doctors in measuring growth of tumors and progress of chemotherapy in cancer patients.

Prof. Cima's work in researching implantable drug-delivery devices has been reported in the October 2002 and the June 2003 Technology Insider and the February 23, 2004 Boston Globe. As reported in Technology Insider, he presented this work at the New Materials track of the MIT Research and Development conference in November 2005.